Effect of transmission model specification on lod score analysis (4)

This graph shows the results of analysing a set of pedigrees using a marker linked to a dominant disease having incomplete penetrance and phenocopies.

The correct model produces the maximum lod score at the true recombination fraction. The Mendelian dominant model produces a lower maximum lod score at an inflated recombination fraction. The recessive model produces completely negative results.

modspec3.html, modspec5.html