The A allele is transmitted to affected offspring four times out of five.
This method of analysis (TDT) attempts to detect markers in linkage disequilibrium with a disease, and by using parental genotypes avoids producing the spurious associations which can occur if controls are not well-matched in case-control association studies. Instead, the parental alleles which are not transmitted to an affected offspring act as controls.
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The A allele is transmitted to affected offspring four times out of five. |