Allele D is found more frequently among cases than controls.
Association between a disease and marker alleles can occur if the disease gene is very tightly linked to the marker, or if the marker polymorphism itself influences susceptibility to the disease.
|
Allele D is found more frequently among cases than controls. |
Association is a very short-range phenomenon and will only be observable for loci which are very tightly linked, and even then only if the disease and marker happen to be in linkage disequilibrium.
"Spurious" assocations can occur if the disease and marker alleles have different frequencies in different subpopulations.