If a marker allele and disease mutation lie close together on the same chromosome they are unlikely to be separated by crossovers during meiosis.
|
If a marker allele and disease mutation lie close together on the same chromosome they are unlikely to be separated by crossovers during meiosis. |
For loci far apart or on different chromosomes recombination will occur by chance in 50% of meioses. The closer the recombination fraction is to 0 the more tightly linked are the loci.